9 Best NAD+ Supplements 2026, Reviewed

NAD+ supplements FAQs, answered:

NAD+ plays a role in energy production and cellular repair to support the ageing process. While more research needs to be done to understand the long-term effects of NAD+ supplements, below are some findings from current studies on its benefits.

• Lower inflammation: Research shows that boosting NAD with supplements like NR may help reduce inflammation, especially in older adults or people with inflammatory conditions.
• Brain health: Some research suggests that supplementing with NR can help with age-related cognitive decline, but more studies are needed to solidify these findings. Research shows that supplementing with NR increases levels of NAD in the brain, and a small study gave 30 people with Parkinson’s disease (a brain disorder) 1,000 mg of NR or a placebo for 30 days and found that those who took the NR had less inflammation in the blood and brain.
• Muscle health and recovery: Your skeletal muscles are rife with mitochondria, and they need NAD+ to make energy for movement. NAD+ helps your muscles generate ATP, the fuel for contractions. “Your cells also need to repair themselves from any damage, and cellular repair requires NAD+,” Amidor says.
• Fertility: Most of the research around NR and fertility is preclinical, meaning studies are conducted in the early stages, typically in labs using cells or animal models. But the data is promising and suggests that elevating NAD+ may support ovarian cell health, Amidor says.

Nicotinamide Mononucleotide (NMN) is a NAD+ precursor that has shown promise in animal studies — but the most efficient and effective way to elevate NAD+ is with the precursor nicotinamide riboside (NR), which is a unique form of vitamin B3 (niacin).

“Unlike the NAD+ molecule itself, NR is the most efficient because it crosses the cell wall directly and requires fewer steps to convert into NAD+,” says Amidor. Finding the best dosage depends on different factors like age and your overall health. “People experiencing digestive absorption challenges and inflammatory conditions typically need elevated doses, as their bodies struggle with absorption while consuming more NAD,” Dr Singh says.

Since NAD is regenerated in the liver, people who drink too much alcohol, take medications like acetaminophen (Tylenol), or have liver issues often have lower NAD levels. They can benefit from higher oral NAD supplementation.

NR is the only NAD+ booster that has no known interactions or adverse effects. Other B3 precursors, such as nicotinic acid (NA) and nicotinamide, do have side effects. At high doses, NA causes intense flushing, and nicotinamide may cause GI issues.

“Oral NR supplementation is the most well-studied form of NAD+ and is well tolerated up to one gram per day,” explains ARTAH founder, nutritionist and naturopath, Rhian Stephenson. “Like most supplements, safety concerns come into play when people decide to mega-dose, so it’s always best to err on the side of caution and not exceed recommended dosing.”

Stephenson adds that NAD+ IVs have the risk — like any IV — of IV site pain, phlebitis, infection risk, vasovagal reactions, etc. “So if you are getting NAD+ infusions, make sure you feel comfortable with the clinic’s hygiene and safety procedures.”

In short, NR supplements are generally well-tolerated, but that doesn’t mean they’re safe for everyone. People with pre-existing cardiac rhythm disorders, particularly atrial fibrillation or other arrhythmias, should check with their doctor before taking NR due to potential heart palpitations. What’s more, NR supplements haven’t been studied in people with cancer or in women who are pregnant or breastfeeding. If you fall into any of these camps, check with your doctor before starting an NR supplement.

A question I wanted answered after seeing NMN all over my FYP. Simply put, NAD+ is an active coenzyme that drives energy and repair, while NMN is a smaller molecule that your body converts into NAD+.

The reason some people are seeking out supplements containing the latter? NMN is stable and can be taken effectively as an oral powder or capsule. Its small size aids absorption. In contrast, oral NAD+ supplements can sometimes struggle to enter your cells intact, due to the fact that they often break down during digestion. For that reason, NAD+ is often administered via intravenous (IV) infusions or injections, bypassing the digestive system.

So, if wanting to reap the benefits often associated with NAD+, it might be best to focus on your dose of NMN instead. But, of course, consult your GP first.

Meet the experts:

How I test the best NAD+ supplements:

Since March 2025, the Glamour team has trialled countless NAD+ supplements — as well as sleep supplements, vitamin D supplements and collagen supplements — in a bid to only recommend the very best. We’ve tested one formulation each for a minimum of six weeks, making sure that everyone who participated in the reviewing process varied in terms of age, skin type and hair type.

At the end of their trial period, they were asked to rate it against the following criteria:

Only the NAD+ supplements that impressed made it into this edit. Read more about how we test here, and in terms of what I’m currently testing, stay tuned for these reviews:

Why you can trust me:

I’ve been a full-time shopping writer for almost three years, writing first-person reviews for the likes of Glamour, GQ and Women’s Health. While I cover most categories, including fashion and gifting, my primary focus has been wellness, meaning my week revolves around testing the latest activewear collections, innovative menstrual health products, new-in sex toys and viral supplements.

To ensure I am an authority on all things wellness, I regularly attend press launches and meet with leading experts or brand founders, quizzing them on common FAQs. I also personally review as many new releases as possible, following a consultation with my dietitian and doctor.

Personally, I struggle with water retention and low energy, often relying on coffee or power naps to make it through the day. Plus, as I fast-approach 30, I’ve become anti-ageing obsessed. As a result, the supplements I tend to reach for — a good probiotic, magnesium glycinate and NAD+ supplements — say they might supercharge my sleep, boost my energy levels and give me that ever-so-popular from-within glow.